Gucy2c Vaccine. CAR-T cell therapy employs bulk T cells … The specific se

CAR-T cell therapy employs bulk T cells … The specific sequence of tumor-directed RT preceding Ad5-GUCY2C IT transformed inactive therapeutic Ad5-GUCY2C vaccination into a curative vaccine. Results: The specific sequence of tumor-directed RT … All patients provided Adenovirus (Ad5)-delivered GUCY2C-based vaccines written informed consent to participate. Here, the cancer vaccine Ad5-GUCY2C-PADRE was evaluated in a first-in-man phase I clinical study of patients with early-stage colorectal cancer to assess its safety and … Phase 2A trial of Ad5. F35 + Lm vaccination regimens and demonstrate that optimal GUCY2C-specific immunity (T-cell quantity, avidity, and … Surprisingly, Lm-GUCY2C vaccination did not prime naïve GUCY2C-specific CD8 + T-cell responses towards the dominant H-2K d -restricted epitope, GUCY2C 254-262. Surprisingly, Lm-GUCY2C failed to prime … Surprisingly, Lm-GUCY2C failed to prime GUCY2C-specific immune responses in mice, despite generating robust Lm-specific immunity. We have created pharmacologics, therapeutic cancer vaccines, and CAR-T cell therapies targeting the cancer antigen GUCY2C (guanylyl cyclase C), … Recently, a phase I trial testing a GUCY2C vaccine safely generated GUCY2C-specific immune responses in patients 33, and an ongoing … Similarly, vaccination of mice with recombinant Lm-GUCY2C expressing the altered peptide ligand (Lm-GUCY2CF255Y) restored GUCY2C immunogenicity and antitumor immunity. 3) and produced GUCY2C-specific im- mune responses (Fig. RESULTS The specific sequence of tumor-directed RT preceding Ad5 … Methods and materials We evaluated the impact of local RT on adenoviral-mediated vaccination against the colorectal cancer antigen GUCY2C (Ad5-GUCY2C) in a murine … All other patient responses are shown in Additional file 1: Figure S1 from publication: Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon … Heterologous prime-boost immunization does not elicit toxicity Previously, GUCY2C-specific vaccines induced systemic anti-tumor immunity without … The Gram-positive bacterium Listeria monocytogenes (Lm) is an emerging platform for cancer immunotherapy. At present, there are surgery, targeted … Immunotherapeutic targeting of GUCY2C encompasses cancer vaccines, immunotoxins, and CAR-T cell therapy, which cover all stages of disease. GUCY2C-specific T cell … Here, we examined a prime-boost strategy comprising GUCY2C-expressing DNA and adenoviral vaccines to enhance antitumor efficacy, identifying a heterologous strategy of … Adenoviral vector vaccines were generated containing guanylyl cyclase C (Ad5-GUCY2C), expressed in normal intestinal epithelium and all primary … More specifically, Lm-GUCY2C may be utilized to amplify GUCY2C-specific immunity in patients receiving adenovirus-based GUCY2C vaccines currently in clinical trials … This paper shows that GUCY2C-specific self-tolerance is mediated by selective CD4 + T-cell tolerance which can be exploited to improve vaccine efficacy without impacting vaccine safety. The progress in the development of … Here, we assessed the immunogenicity of an Lm vaccine against the colorectal tumor antigen GUCY2C (Lm-GUCY2C). … In the study, immunization with GUCY2C-based vaccines generated memory CD8 + T-cell responses that provided durable … Conversely, mice bearing GUCY2C-deficient (CT26-WT) or GUCY2C-expressing (CT26-GUCY2C) tumors received 8 Gy radiation to the tumor … Here, we examined the immunogenicity of an Lm-based vaccine expressing the colorectal cancer antigen guanylyl cyclase C (Lm-GUCY2C). The progress in the development of … GUCY2C vaccines focus on minimum residual disease in colon cancer patients and aim to reduce the recurrence rate (27). We evaluated the immunogenicity of Ad5. Endogenous GUCY2C-activating ligands disappear early in … For the last decade, we have focused on guanylyl cyclase C (GUCY2C) as a potentially ideal target antigen for colorectal cancer immunotherapy. Patient blood samples were collected before (day 0) and 30, 90 and 180 days … Indeed, incorporating immunogenic Lm peptides into an adenovirus-based GUCY2C vaccine previously shown to induce robust … Figures for SABCS 2017P6-11-16 - Dysgeusia, weight and eating habits changes in breast cancer patients undergoing chemotherapy: A prospective cohort study This review outlines the role of GUCY2C in tumorigenesis, and steps to translate GUCY2C-targeting schemes to the clinic. Ten percent of patients … Supporting: 1, Mentioning: 56 - Background The colorectal cancer antigen GUCY2C exhibits unique split tolerance, evoking antigen-specific CD8 + , but not CD4 + , T-cell responses that … To overcome this challenge, we generated a GUCY2C vaccine employing a chimeric viral vector composed of the Ad5 capsid and Ad35 fiber protein (Ad5. F35). Compositions comprising a … Three Primary Modalities for GUCY2C-directed Cancer Immunotherapy. F35-GUCY2C-PADRE vaccine for recurrence prevention in gastrointestinal (GI) adenocarcinomas post definitive surgery and adjuvant therapies. 3ojita
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